I've heard that some people react well to Ritalin / Cocaine while others react well to amphetamines. Dexerdrine should be talked about more, it’s just like vyvanse but works much faster and smoother. Adderall vs Vyvanse comparison. In the body the inactive prodrug get's metabolised and the L-Lysin amino accid get's seperated from the dextroamphetamine (this happens in red blood cells which means road of administration does not effect pharmacokineticcs much). Maybe it's because eating it is the only viable option? Once lisdexamfetamine is inside the body it gets converted into dextroamphetamine (its active form) as soon as it touches red blood cells.2, Because Adderall and Vyvanse both contain amphetamines they work in a similar way, and that is by blocking the re-uptake of two neurotransmitters (chemical substances that help nerves talk to each other) in the body. Interpretive Report. Thanks extasis, Adderall is more jittery but they both give off the same euphoria for me, more or less. The FDA approved Adderall in 1996, and Vyvanse has been available since 2007. I have since taken vyvanse around 10 times, and have only taken adderal one other time due to it not being near as euphoric to me as the vyv. I was a bit torn but went for Concerta and have titrated to a relatively high dose for a new starter (no side effects though). Lisdexamfetamine is only available as Vyvanse, at a cost of $884 for 100 capsules ($8.84 per capsule).15 Don't hold your breath for a generic - one isn't expected until 2023!16, No. I prefer vyvanse much much much more than adderal, vyvanse was everything I was hoping adderal would be. Vyvanse causes me to become very talkative, thoughtful and causes me to think much much deeper and just feels good, adderal causes me to feel an uncomfortable sense of speed (makes me feel too much like a tweaker honestly) and caused me too feel anger and negative emotions much quicker, nowhere near the same amount of euphoria from vyv. Like, I couldn't move, I just had to keep doing something, regardless if it was important or not. Martin PT, Corcoran M, Zhang P, Katic A. Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the Effects of Lisdexamfetamine Dimesylate and Mixed Amphetamine Salts on Cognition Throughout the Day in Adults with Attention-Deficit/Hyperactivity Disorder. The dextroamphetamine is the one that is mainly responsible for it's actions on your cognition. https://www.reddit.com/r/FADQ/comments/buyhp5/on_adderall/. I think Adderall became the new, improved version of Dexedrine and has virtually replaced it. Methylphenidate is my least favorite medically, but if I had to pick one to abuse it would probably be MPH. I've never had euphoria from either. So it is less likely to be misused than Adderall … My doctor switched me from adderall xr to concerta because I said I wanted to try IR because if I take xr before work I pretty much don’t feel it by the time of my night class and he doesn’t want to prescribe IR for potential of abuse, so he said concerta should last longer.